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Information provided on personal blogs and commercial websites advises fitness and bodybuilding enthusiasts to supplement with ostarine at dose ranges from 10 mg to 30 mg for at least 12 weeks. Several studies have shown ostarine to increase bodyfat while decreasing total fat mass and preserving lean tissue [4,10,35]. A dose-response relationship has yet to be identified between ostarine uptake and fat loss, but one animal study found that supplementation with 5 mg or 20 mg of ostarine per day for a period of 2 weeks resulted in greater than 10% improvements in bodyfat . However, other studies have demonstrated low body fat gains after ostarine supplementation [2,13,16,36]. The purpose of this study was to investigate the effect of ostarine on fat loss between 12 weeks and 6 months following discontinuation of resistance training, an active treatment in its own right. Methods Participants and Procedures This study evaluated the effects of ostarine supplementation on body composition, body energy expenditure, resting metabolic rate (RMR), and hormonal response. Inclusion criteria was a male 19-30 years of age with 2–4 years of resistance training experience who was using an energy drink with ostarine or placebo in the previous 2 weeks prior to participation in this study. Exclusion criteria ranged from using weight training equipment or assistance exercises to use of an energy drink for more than 10 sessions per month or more than 30 minutes of physical activity per week. Only men with a Body Mass Index of greater than 30 kg/m2 were eligible to be studied. After completion of an initial physical examination (body composition) and weight training (body energy expenditure), participants completed a 7-day dietary and beverage diary to estimate energy expenditures (calories) while consuming a daily energy supplement (placebo; total weight = 150 and body mass = 85 kg), a resistance exercise treatment (RS; total weight = 150, body mass = 85 kg), or a high-intensity weight training or exercise treatment (HIT; total weight = 140 and body mass = 68 kg; HIT = 25 x 3 repetition maximum / min, HITT = 30 x 3 repetition maximum / min; HIT = 30 min x 10 repetition maximum / min; HIT = 30 min x 10 second maximum / min), and the effects of ostarine (1 or 2 mg/kg) and placebo intake on body composition, energy expenditure, and hormonal response. At baseline and 12 days following discontinuation of resistance training, we measured body compositions, blood lactate, resting metabolic rate, total water, and urine electrolytes in each participant, a portion of each subject was also measured Related Article: